Disease Highlights the Cellular Diversity of Neurovascular Units: Sign in Stranger.

Clinical and basic evidence suggests that both large artery and small vessel disease contribute to the pathogenesis of Alzheimer disease, one form of dementia. Although the study of the cause of Alzheimer disease began with a vascular emphasis, the field shifted to a focus on neuronal changes in response to local amyloid β peptides (Aβ), subsequent Tau pathology, and their ultimate effects on cognitive function. In more recent years, a partial realignment has occurred, such that vascular disease is again thought to make important contributions to Alzheimer disease pathology (along with other dementias) and their impact on brain function.